Brucellosis, a neglected disease
Summary
Brucellosis is a zoonosis(1), an infectious disease due to bacteria of the Brucella genus, which can affect most animals - domestic and wild species. In animals, the infection may cause abortions in females, epididymo-orchitis in males and, less frequently, arthritis or bursitis in both. Mucosal contact with aborted fetuses and fetal membranes, which contain large amounts of the bacteria, is an important means of transmission in livestock.
Fifty years ago, the Brucella genus was considered to contain only 3 species: Brucella abortus, Brucella melitensis, and Brucella suis. Since the early 1960s, new species have been identified as belonging to the Brucella genus. Although the pathogenesis and histologic lesions of B. abortus, B. melitensis, and B. suis in their preferred hosts have not changed, additional knowledge on the pathology of these brucellae in new hosts, or of new species of Brucella in their preferred hosts, has been obtained (Online WOAH Terrestrial Manual, Chapter 3.1.4).
To this day, brucellosis remains a neglected human zoonosis that is emerging or reemerging in many parts of the world. It places significant burdens on human healthcare systems and limits the economic potential of individuals, communities, and nations. The implementation of public policy focused on mitigating the socioeconomic effects of brucellosis in human and animal populations is needed. The interdisciplinary “One Health” nature of the effects that brucellosis has indicate that collaboration of veterinary, medical, public health, cultural, economic and social experts is needed to effect a change in disease burden (Berthe et al, 2018; Franc et al, 2018).
(1) Zoonosis : a disease, communicable from animals to humans under natural conditions, due to microbes, parasites or prions capable of infecting at least one vertebrate animal, transmission taking place from animal to humans or vice-versa.
Legal notices
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Publisher
French Agency for Food, Environmental and Occupational Health & Safety
14 rue Pierre et Marie Curie
94701 MAISONS-ALFORT cedex
Tel.: +33 (0)1.49.77.13.50
Publication Director: Benoît Vallet, General Director of ANSES
Site technical administrator: Olivier Cohen
Site scientific administrators: Claire Ponsart
Host
French Agency for Food, Environmental and Occupational Health & Safety
14 rue Pierre et Marie Curie
94701 MAISONS-ALFORT cedex
Tel.: +33 (0)1.49.77.13.50
Personal data
ANSES, represented by its Director General, has responsibility for the processing of personal data intended for managing the reference activities of the ANSES foot-and-mouth disease laboratory (EURL FMD). The Data Protection Officer is the Director of Legal Affairs (saisine-daj@anses.fr). Personal data accessible via an authenticated connection and available for information are never divulged to third parties. In accordance with the provisions of the General Data Protection Regulation (GDPR) and the French Data Protection Act of 6 January 1978, as amended, you have a right to access and rectify any information that concerns you. You can also, for any legitimate reason, object to the processing of any data concerning you. You can exercise your rights by contacting: eurl.brucellosis@anses.fr.
Intellectual property
The EURL Brucellosis website is the property of ANSES and is entirely covered by French and international legislation on intellectual property. All rights are reserved, including those of reproduction, distribution and transmission. Any use of the information contained on the site, regardless of its form, and particularly texts, photographs and diagrams, is subject to ANSES's prior authorisation.
Establishment of links
Any public or private site – with the exception of sites disseminating information that is illegal or of a particularly polemic, pornographic, sectarian or xenophobic nature – may, without prior authorisation, establish a link to the home page or directly to the information distributed by the EURL Brucellosis website. However, under no circumstances shall the pages of the EURL Brucellosis website (https://eurl-brucellosis.anses.fr/) be embedded within the pages of another site. All efforts shall be made to indicate clearly to the user that they are visiting the EURL FMD website and to enable them to browse freely.
In other cases, and particularly:
- if the site content is to be integrated into the navigation of the requesting site,
- if access to the pages containing the link to the EURL Brucellosis website is not free of charge, a request for authorisation must be submitted to ANSES via eurl.brucellosis@anses.fr.
ANSES reserves the right to request the removal of a link that it considers does not comply with its editorial policy or may harm its image, without prejudice to any subsequent actions before the competent courts.
For its part, ANSES establishes links only on public websites and shall not be liable for any links towards its own site.
However, if you create a link to the EURL Brucellosis website we ask you to inform us eurl.brucellosis@anses.fr.
Photographic credits
Credit: iStock, AdobeStock.
The photos are not free of copyright.
Web credits
The EURL Brucellosis website was developed by JOUVE.
Workshop 2019, September 19-20, ANSES
EURL for Brucellosis
We are pleased to invite you to the 12th Brucellosis Annual Workshop
The workshop will be held on 19 and 20 September in Anses - Maisons-Alfort and will cover, among others, the following topics :
- Annual NRLs activity report
- Update in serological methods
- Molecular biology : survey on PCR methods
- Use of full genome sequencing : Phylogeny / WGS / in silico typing
Please let us know if you like to submit free communications / posters for our next workshop !
Programme is ongoing
On Thursday 19 evening, we will organize a visit in Centre Georges Pompidou (see below)
The restaurant (Au pied de cochon) price is 60 €, and will be deducted from your daily allowances.
If you wish to participate in the evening, we inform you that you will have to buy 2 metro tickets
Kindly register online (1 form submitted per person attending) to the workshop by 2019, August 9 even if you cannot attend the workshop.
Please note that only one person per NRL is eligible for reimbursement.
Please take the opportunity of the form to propose any topic you wish to present as there will be a time dedicated for NRLs communication.
Lunch will be arranged by ANSES on Thursday 19 and Friday 20 and will take place in our cafeteria on Thursday and you are to pay directly to them.
Please bring some cash with you to cover for lunch. There is no fixed price, it depends on what you eat, but lunch might cost 10-15 euros…
The instructions related to your journey, stay and reimbursement procedure are detailed below (Practical information).
Please read Practical information before any booking
to contact us
- Access map to ANSES
Metro ligne 8 Station "Ecole Vétérinaire de Maisons-Alfort" to ANSES : 11 min walk
RER D station "Maisons-Alfort Alfortville" to ANSES : 14 min walk
Possibilities to Maisons-Alfort Transport
- Public transport service maps and information RATP website : www.ratp.fr
- How to get from the Airports and train station to Maisons-Alfort :
- From Paris-Charles de Gaulle airport to Maisons-Alfort
- From Paris-Orly Sud Airport to Maisons-Alfort
- From Paris-Gare du Nord train station to Maisons-Alfort
Practical information-Transport
Flights/trains tickets will not be booking by Anses.
Before any booking, please send us your hour of departure and arrival (to come and return)
Please, register your journey wishes here
DEMAND FOR EXTENSION OF STAY BEFORE BOOKING YOUR TRAVEL
If you want to stay for personal reasons, in this case your stay costs related to this extension cannot be paid by Anses.
So you will have to contact yourself with the hotel to reserve the additional nights.
We have already booked the hotel rooms for eligible participants in Kyriad, Petit Caporal and Adagio Hotels.
Anses will pay the nights of the 18 and 19 September 2019 to the hotel.
The following hotel are near to Anses (walking distance)
. Hotel Kyriad Paris Est Porte de Bercy Saint Maurice
From Kyriad hotel to ANSES : 17 min walk
. Hotel Le Petit Caporal
From Au Petit Caporal to ANSES : 9 min walk
. Hotel Adagio
From Hotel Adagio to ANSES : 11 min walk
Administrative and Financial issues here
In order to simplify administrative issues we will manage your stay and pay directly the hotels bills.
We may inform you that only 2 nights (18 and 19 September) are eligible if you don’t apply for an extension of stay for reduced fare rate.
As soon as possible before the event
Please send by e-mail the Financial Identification Form (FIF) - The FIF enables us to identify the payee. Without it the participant will pay directly all the costs.
15 days after the event
ORIGINAL return boarding pass/train ticket must be sent back in a 2-weeks delay after the event (meeting/training session/workshop) to :
ANSES Laboratoire de Santé Animale - UZB Marie-France DEVAUX ACI-ROU-009 14, rue Pierre et Marie Curie F- 94 701 MAISONS-ALFORT cedex FRANCE
An envelop will be available in your participant's folder.
Reimbursement will only be processed once all proofs of expenditure are sent by post mail.
to contact us
Looking forward to meeting you in september
CDC Advisory: Third Case of Rifampin/Penicillin-Resistant Strain of RB51 Brucella from Consuming Raw Milk
[relayed from CDC Health Alert Network]
The New York State Department of Health and Pennsylvania Department of Health are investigating Brucella RB51 exposures that may be connected to consuming raw (unpasteurized) milk from Miller’s Biodiversity Farm in Quarryville, Pennsylvania. Symptoms of brucellosis can include fever, sweats, malaise, anorexia, headache, fatigue, muscle and joint pain, and potentially more serious complications (e.g., endocarditis, hepatomegaly, splenomegaly, and neurologic symptoms). In pregnant patients, Brucella infections can be associated with miscarriage. Symptom onset can occur anywhere from five days to six months following exposure. As of January 22, 2019, exposures have been identified in 19 states: Alabama, California, Connecticut, Florida, Georgia, Iowa, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, New Jersey, New York, North Carolina, Ohio, Pennsylvania, Rhode Island, South Carolina, and Virginia.